111SKIN is the culmination of twenty years of surgical knowledge, high-tech ingredients, and cutting-edge innovation. Founded by globally renowned Harley Street cosmetic surgeon Dr. Yannis Alexandrides, the original formula was developed to help his patients’ skin heal after trauma and given complimentary after treatments for more effective results and improved healing time. Collaborating with space scientists who researched the acceleration of aging in astronauts, Dr. Yannis wanted to produce a product which could induce skin’s own reparative processes to alleviate scarring and inflammation and protect against environmental pollutants.  The formula included NAC Y2, a trio of actives with superior antioxidant capabilities, one of which stimulates the production of Glutathione – the body’s most powerful intracellular antioxidant. After noticing astronauts' skin looking younger and feeling smoother, patients started requesting more of the serum and soon demand outstripped supply.

It became the principal ingredient in the original 111SKIN product the Y Theorem Repair Serum, and then throughout the entire Reparative range. It is a powerful ingredient in skincare because of its varied and high antioxidant content, helping to improve resilience, protect from environmental aggressors, brighten the complexion, and rejuvenate skin.

NAC Y2 is made up of:
N-acetylcysteine (NAC): The N-acetyl derivative of amino acid L-cysteine (the precursor for glutathione – an important antioxidant which is produced by the body).
Ascorbyl Phosphate: A stable Vitamin C derivative and antioxidant.
Aesculus hippocastum extract: The active ingredient is Escin, which is an antioxidant and vasoprotector.

Blieving in prevention, rather than intervention, as means of maintaining skin health and vitality he realised that many people could benefit from this formula, and worked together with his wife Eva to create the 111SKIN brand, evolving from one single product to five ranges. Taking inspiration from his 111 Harley Street clinic, each product is carefully researched and formulated to address specific skincare concerns that he sees on a daily basis such premature aging, oily or spot-prone skin, lackluster complexions, hyperpigmentation, and dehydration. There are also targeted products that are focused on damage-prone areas such as the neck and décolletage, under eyes, and lips. 111SKIN is committed to delivering skincare which is science-led, pioneering, medically-inspired, and able to provide results that are comparable to in-clinic procedures.

According to Dr. Yannis Alexandrides, they bring clinically-inspired skincare that addresses real-life concerns to customers. Using his 20+ years of expertise and medical observations, they develop products using innovative formulas that are engineered using the most sophisticated methods for efficient penetration of the skin and the highest levels of efficacy. They strive to bring the best of Harley Street to home, creating skincare that can replicate in-clinic treatments, all while feeling opulently indulgent and sensorial pleasure.